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MTF Hormone Replacement Therapy Philippines Routine

Before anything else, this isn’t a guide. This is my personal MTF Hormone Replacement Therapy Philippines routine.

I am not a specialist nor a doctor so take this with a grain of salt.

However, if you’re a transgender woman from the Philippines and are new to this, keep reading as it’ll give you some insight on where to begin.

MTF Hormone Replacement Therapy Philippines Routine

by Amanda of Filipinow

I started self-medicating when I was 16 years old with Micropil. When I turned 18, I leveled-up to Diane 35.

Both are birth control pills which contain a synthetic estrogen called ethinyl estradiol, which poses risks when taken regularly.

Some of the adverse effects that one can get from taking ethinyl estradiol are liver damage, blood clots, and cancer of the uterus (which doesn’t apply to transwomen).

There are 2 types of medication that you’ll need as a transgender woman if you have not undergone orchiectomy (pagpapatanggal ng bayag) or sexual reassignment surgery yet.

I’m going to explain them in layman’s term because I am not a specialist and to not further confuse you.


Progynon Depot Philippines

This is the main hormone that would turn your feminization dreams into reality. Genetic women produce this hormone dominantly. It’s also responsible for their softer skin, curvier bodies, rounder faces, wider hips, and breast growth.

However, please know that it doesn’t affect hair growth on the face. If that’s your issue, diode laser is the best and most affordable option for you.

Its bioidentical drug forms are usually called Estradiol Valerate (what I use), Estradiol Benzoate, Conjugated Estrogen, Estradiol, and a whole lot more.

When talking about MTF Hormone Replacement Therapy Philippines routine, it’s imperative to take bioidentical medication in order for your doctor to properly diagnose you of the right amount of dosage as this one is the only type that appears in blood tests.

Ethinyl Estradiol, however amazing its effects are physically speaking, have grave adverse effects and won’t let your doctor determine if you’re overdosed or underdosed.

Estradiol Valerate

The very reason why I prefer injectable Estradiol Valerate (Progynon is the brand that I use) is the efficacy’s duration. 1 vial can last up to 7-8 days. Suffice to say, in my case, I only need to administer it once a week.

Please know that we have different estrogen levels so it’s best to consult your physician.

There is one Filipina YouTuber who shares a lot of content about MTF Hormone Replacement Therapy Philippines. You’ll surely learn how to get started step-by-step through her channel. Don’t forget to subscribe!

Apart from HRT tips, Destiny Maylas also shares a lot of invaluable content plus she’s funny and cute and is a joy to watch.

My Experience with Estrogen

With Diane35 (Ethinyl Estradiol), I’ve noticed that my food cravings were always present. My libido wasn’t affected but I was more moody, lazy, and weak. My breasts were always sore and I also barely grew zits when I was on it and my skin looked more glowing.

However, with Progynon Depot (Estradiol Valerate), I only feel weak and lupaypay within 24 hours after injection. I find that I’m more stable emotionally with it but I don’t feel as “beautiful” (I think it’s more mental) as I did with birth control pills.

PS: I was taking 3 Diane35 pills a day before bedtime which was purely self-medication and could’ve meant that I was overdosing. Don’t include Birth Control Pills in your MTF Hormone Replacement Therapy Philippines routine.

Let’s move on to the 2nd section…


This comes in 2 popular drug forms which are spironolactone and cyproterone acetate. The reason why Diane35 is very popular amongst Asian transgender women is because it contains both estrogen (synthetic) and anti-androgen.

Diane35 Ingredients

Anti-androgens are testosterone blockers which is pretty much self-explanatory.

They block a good amount of testosterone (male hormone as most call it) which most transgender women dominantly produce.

Testosterone is responsible for muscle development, body hair growth, bone density, enhanced libido, musky scent of sweat, and other factors that most transwomen don’t want to be associated with lol.

While a high amount of estrogen can block testosterone, doctors still diagnose testosterone blockers to transgender women who have not undergone orchiectomy or sexual reassignment surgery yet for a more effective transition.

My Experience

Hyles Spironolactone Ingredients

I’ve tried both Spironolactone and Cyproterone Acetate.

Cyproterone Acetate was introduced to me in 2 forms, Diane35 and Androcur. I’ve noticed that both drugs made me feel very weak and less productive. However, both didn’t affect my libido which is very surprising as the latter was created to chemically castrate rapists back in the day. Another reason as my libido may have stayed intact is because I was using both before bedtime. Testosterone levels are high when a person just wakes up (hello morning wood).

What I noticed when I’m on spironolactone (Hyles or Aldactone) is that I always pee. It’s the reason why it should be taken right after waking up in order to not disturb one’s sleep. My libido is not as high but it comes back at night time which is, to be honest, just about right because I don’t like feeling frisky in the daytime. I have too much work to do lol!

Physically, both are very satisfactory in results. I’ve never had a muscular body to begin with but I find that it’s easier to eat healthily when I’m under spironolactone.

Again, this is not an MTF Hormone Replacement Therapy Philippines guide, this is my routine.

If you want to know the right medication for your MTF HRT in the Philippines, you can visit Victoria by LoveYourself.

Victoria by LoveYourself is the first community center in the Philippines that focuses on Transgender Health services. They offer FREE gender-affirming hormone management, and pre-GAS (Gender affirming surgery) assessment and counseling.



Average dosage of an MTF transgender woman undergoing Hormone Replacement Therapy is:

Estradiol Valerate = 10mg per week

Spironolactone = 100mg a day (not needed if you had an orchiectomy or SRS)

  • Do not use birth control pills for HRT.
  • Don’t mix different types of estrogens.
  • Cyproterone acetate poses more risks and it is banned in the US. Spironolactone is easier on the liver.
  • Ask your doctor first before taking spironolactone.
  • HRT’s goal is to give you the same hormone levels of the average genetic woman. Overdosing won’t turn you into Angelina Jolie.
  • HRT alone doesn’t turn you into a woman. It should start from within. Don’t do it just to look “prettier” as it is not a beauty regimen and some effects are irreversible.

Did you learn anything from my MTF Hormone Replacement Therapy Philippines routine? Please share it on your timeline.

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Signature of Amanda

An Aquarius full time Spinster and Poodle mom.


  • Jaycee

    Hi Amanda! I’ve read online that Progynon Depot was discontinued by Cadila since 2016. And there are fake Progynon Depots being sold in Southeast Asia.

    Do you know if this is true? My friend referred me to a seller and I’ve just purchased myself a box of Progynon Depot (similar to the picture you posted above). I’m afraid I’m spending money and injecting for nothing. Please help me. 🙁

    • amandadelacruz

      Hi Jaycee,

      Yes, there was an influx of fake Progynon Depots. For now, just buy from sellers who sell Japanese Progynon or if you want a budget-friendlier version, try Phenokinon F.

      Thanks for dropping by!

  • Joemar

    Hi miss… I am planning to take hyles 100? Gano ko po sya katagal pwede gamitin…?

    Reason of taking dis is ung mga unwanted body hair ko mostly sa face para mabawasan lang sana pagtubo…

    And also nagtetake kasi ako biotin for hair hndi kaya maapektuhan un na di na tumubo kase napapanot ako hehe… Kase sa hyles diba prinprevent ang excess growth of body hair…?

    Thank you in advance

    • amandadelacruz

      Yes sa body hair not totally prevent pero bumabagal. Kahit anong hormones d makakatulong sa pag pabagal ng pag grow ng facial hair kasi malakas circulation ng dugo sa mukha kaya mabilis tlga tumubo ang facial hair. Kahit biological women may ganun so ang magandang solution para sa balbas at bigote is diode laser hair removal talaga. Good luck sis!

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